WDR48

WD repeat domain 48

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

WDR48 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human WDR48 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G73490

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76 kDa

Price:

20 µg/$1,107

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Human WDR48 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G95382

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76 kDa

Price:

20 µg/$150

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Human WDR48 Protein (Recombinant GST) (Full Length) - LS-G34753

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83 kDa

Price:

10 µg/$479; 25 µg/$670

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WDR48 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110946

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

76 kDa

Price:

100 µg/$494

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