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WDR19 is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.
Gene Name: | WD Repeat Domain 19 |
Synonyms: | WDR19, ATD5, CED4, DYF-2, KIAA1638, NPHP13, IFT144, ORF26, PWDMP, WD repeat domain 19 |
Target Sequences: | NM_025132 NP_079408.3 Q8NEZ3 |
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