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Required for selective autophagy (aggrephagy) but not for autophagic degradation of bulk cytospol in response to starvation. Involved in the formation and degradation of cytoplasmic polyubiquitin-containing bodies (p62 bodies, ALIS/aggresome-like induced structures). May play a role as adaptor or scaffolding protein by promoting the association of the E3-like ligase ATG12-ATG5-ATG16L and LC3 to ubiquitinated target substrate. The association with GABARAP is required for its recruitment to LC3B-positive p62 bodies suggesting a role in targeting certain p62 structures for clearance. Involved in midbody ring degradation.
Gene Name: | WD repeat and FYVE domain containing 3 |
Synonyms: | WDFY3, ALFY, Autophagy-linked FYVE protein, KIAA0993, ZFYVE25 |
Target Sequences: | AB023210 BAA76837.2 Q8IZQ1 |
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