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WC1 / ATP7B

ATPase, Cu++ transporting, beta polypeptide

WC1 / ATP7B is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein functions as a monomer, exporting copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease (WD).

Gene Name: ATPase, Cu++ transporting, beta polypeptide
Family/Subfamily: Transporter , ATPase - P type, type IB
Synonyms: ATP7B, Copper-transporting ATPase 2, WC1, Wilson disease, PWD, WD, Copper pump 2, WND
Target Sequences: NM_000053 NP_000044.2 P35670

Publications (3)

1
NH2-terminal signals in ATP7B Cu-ATPase mediate its Cu-dependent anterograde traffic in polarized hepatic cells. Guo Y, Nyasae L, Braiterman LT, Hubbard AL. American journal of physiology. Gastrointestinal and liver physiology. 2005 289:G904-16. (WB; Human, Rat) [PubMed:15994426]
2
Characterization of Sandwich-Cultured Hepatocytes as an In Vitro Model to Assess the Hepatobiliary Disposition of Copper. John H. Ansede, Matthew R. Wright, Robert L. St. Claire III,. Drug metabolism and disposition: the biological fate of chemicals. 2009 37:969-76. (WB; Dog, Human, Rat) [Full Text Article] [PubMed:19237514]
3
Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Chen HH, Yan JJ, Chen WC, Kuo MT, Lai YH, Lai WW, Liu HS, Su WC. Lung cancer (Amsterdam, Netherlands). 2012 Feb;75:228-34. [Full Text Article] [PubMed:21788094] [PMC:PMC3319119] Related Antibodies: LS-B2302.

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WC1 / ATP7B (2)
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WC1 / ATP7B ELISA Kit
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0.156 - 10 ng/ml
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WC1 / ATP7B ELISA Kit
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).