WAS / WASP

Wiskott-Aldrich syndrome

The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

WAS / WASP (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human WAS / WASP Protein (Recombinant His-T7) (aa39-251) - LS-G24553

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.9 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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Human WAS / WASP Protein (Recombinant GST, N-terminus) (aa57-170) - LS-G60519

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human WAS / WASP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67344

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

20 µg/$1,107

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Human WAS / WASP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79594

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

20 µg/$150

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Rat WAS / WASP Protein (Recombinant His-T7) (aa1-298) - LS-G24554

Source:

E. coli

Tag:

His-T7

Molecular Weight:

36.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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WAS / WASP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123231

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.7 kDa

Price:

100 µg/$494

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