VRK2

vaccinia related kinase 2

Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant.Isoform 2 phosphorylates 'Thr-18' of p53/TP53, as well as histone H3. Reduces p53/TP53 ubiquitination by MDM2, promotes p53/TP53 acetylation by EP300 and thereby increases p53/TP53 stability and activity.

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Products

Antibodies (24)

Type

Primary (24)

Target

VRK2 (24)

Reactivity

Human (17)

Mouse (11)

Application

IHC (2)

IHC-P (1)

WB (20)

ELISA (14)

IF (2)

IP (1)

Peptide-ELISA (2)

RNAi (1)

Host

rabbit (17)

mouse (7)

Isotype

IgG (16)

IgG1 (4)

IgG1,k (1)

IgG2b (2)

Clonality

monoclonal mc (7)

polyclonal pc (17)

Clone

3B10 (1)

OTI2A2 (2)

OTI2F5 (2)

OTI8H5 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (3)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (16)

Epitope

aa354-381 (7)

aa301-486 (6)

140-220 aa, Internal (1)

aa171-220 (1)

Publications

No (24)

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VRK2 Antibody LS-C810169

Antibody:

VRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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VRK2 Antibody (clone 3B10) LS-C198433

Antibody:

VRK2 Mouse anti-Human Monoclonal (3B10) Antibody

Reactivity:

Human

Applications:

ELISA, IF, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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VRK2 Antibody LS-C681692

Antibody:

VRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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VRK2 Antibody (HRP) LS-C681696

Antibody:

VRK2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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VRK2 Antibody (Biotin) LS-C681694

Antibody:

VRK2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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VRK2 Antibody (FITC) LS-C681695

Antibody:

VRK2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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VRK2 Antibody LS-C661580

Antibody:

VRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

VRK2 Antibody (aa354-381) LS-C326297

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

VRK2 Antibody (aa354-381, Biotin) LS-C273387

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

VRK2 Antibody (aa354-381, FITC) LS-C273388

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) (FITC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

VRK2 Antibody (aa354-381, Azide-free, HRP) LS-C273389

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

VRK2 Antibody (aa354-381, PE) LS-C273390

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) (PE) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

VRK2 Antibody (aa354-381, APC) LS-C273386

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) (APC) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• PE
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • PE
  • APC

Select

VRK2 Antibody (140-220 aa, Internal) LS-C386652

Antibody:

VRK2 Rabbit anti-Human Polyclonal (140-220 aa, Internal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

VRK2 Antibody LS-C824591

Antibody:

VRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

VRK2 Antibody (aa171-220) LS-C120375

Antibody:

VRK2 Rabbit anti-Human Polyclonal (aa171-220) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

VRK2 Antibody (aa354-381) LS-C158285

Antibody:

VRK2 Rabbit anti-Mouse Polyclonal (aa354-381) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

VRK2 Antibody (aa301-486, clone OTI2A2) LS-C795936

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (OTI2A2) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

VRK2 Antibody (aa301-486, clone OTI2A2, Carrier-free) LS-C792770

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (Carrier-free) (OTI2A2) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

VRK2 Antibody (aa301-486, clone OTI2F5) LS-C799908

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (OTI2F5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

VRK2 Antibody (aa301-486, clone OTI2F5, Carrier-free) LS-C792771

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (Carrier-free) (OTI2F5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

VRK2 Antibody (aa301-486, clone OTI8H5) LS-C799909

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (OTI8H5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

VRK2 Antibody (aa301-486, clone OTI8H5, Carrier-free) LS-C792773

Antibody:

VRK2 Mouse anti-Human Monoclonal (aa301-486) (Carrier-free) (OTI8H5) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

VRK2 Antibody LS-C747397

Antibody:

VRK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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