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VPS72
vacuolar protein sorting 72 homolog (S. cerevisiae)
VPS72 is a shared subunit of two multi-component complexes, the histone acetyltransferase complex TRRAP/TIP60 as well as the chromatin remodeling SRCAP-containing complex. The TRRAP/TIP60 complex acetylates nucleosomal histones important for transcriptional regulation, double strand DNA break repair and apoptosis. The SRCAP-containing complex catalyzes the exchange of histone H2A with the histone variant Htz1 (H2AFZ) into nucleosomes. This protein may be responsible for binding H2AFZ, which has a role in chromosome segregation. This protein may also have a role in regulating long-term hematopoietic stem cell activity. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
| Gene Name: | vacuolar protein sorting 72 homolog (S. cerevisiae) |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | VPS72, Protein YL-1, TCFL1, Swc2, Transcription factor-like 1, YL1, YL-1 |
| Target Sequences: | NM_005997 NP_005988.1 Q15906 |
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