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VPREB3
pre-B lymphocyte 3
VPREB3 is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas.
| Gene Name: | pre-B lymphocyte 3 |
| Synonyms: | VPREB3, 8HS20, N27C7-2, Pre-B lymphocyte 3, Pre-B lymphocyte gene 3, Pre-B lymphocyte protein 3, Protein VPreB3 |
| Target Sequences: | NM_013378 NP_037510.1 Q9UKI3 |
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