VNN1

Vanin 1

Vanin1 (pantetheinase) is an amidohydrolase that catalyzes the hydrolysis of D-pantetheine, permitting the recycling of pantothenate (vitamin B5) and the generation of an antioxidant metabolite, cysteamine. Vanin-1 is a glycosylphosphatidylinositol (GPI)-anchored molecule expressed by perivascular thymic stromal cells. Antibody against vanin-1 blocked thymus colonization by hematopoietic progenitor cells in both short- and long-term assays and interfered with lymphostromal cell adhesion. It is suggested that vanin-1 regulates late adhesion steps of thymus homing under physiologic, noninflammatory conditions. In addition the pantetheinase activity of the vanin-1 molecule is thought to be a major regulator of intestinal inflammation, acting through cysteamine release. Vanin1 (-/-) mice displayed a drastically reduced incidence of colorectal cancer.

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Proteins (14)

Type

Over-Expression Lysate (2)

Recombinant (12)

Target

VNN1 (14)

Publications

No (14)

Tag

6His, C-terminus (2)

Fc (1)

GST (1)

GST, N-terminus (1)

His (6)

His-T7, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Bovine (1)

Human (8)

Mouse (3)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (1)

Human Cells (3)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (4)

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Human VNN1 Protein (Recombinant GST) (Full Length) - LS-G31380

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Rat VNN1 Protein (Recombinant His-T7, N-terminus) (Ser22-Pro328) - LS-G133605

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

37.8kDa

Price:

10 µg/$276; 50 µg/$412; 200 µg/$822; 100 µg/$657; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Human VNN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88074

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.02 kDa

Price:

20 µg/$215

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Bovine VNN1 Protein (Recombinant His) (aa216-469) - LS-G24981

Source:

E. coli

Tag:

His

Molecular Weight:

32.1 kDa

Price:

10 µg/$286; 50 µg/$472; 100 µg/$752; 200 µg/$942; 1 mg/$2,069; 500 µg/$1,600; 5 mg/$3,291; 2 mg/$2,257

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Human VNN1 Protein (Recombinant GST, N-terminus) (aa298-397) - LS-G60914

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse VNN1 Protein (Recombinant His) (Met1-Ser487) - LS-G98868

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.4 kDa

Price:

100 µg/$721

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Mouse VNN1 Protein (Recombinant Fc) (Met1-Ser487) - LS-G98869

Source:

Human Cells

Tag:

Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

79 kDa

Price:

100 µg/$843

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VNN1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100363

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.02 kDa

Price:

100 µg/$710

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Human VNN1 Protein (Recombinant 6His, C-terminus) (Gln22-Ser490) - LS-G39052

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.27kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human VNN1 Protein (Recombinant 6His, C-terminus) (Gln22-Ser490) - LS-G139720

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.3 kDa

Price:

10 µg/$288; 50 µg/$436

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Human VNN1 Protein (Recombinant His) (aa36-223) - LS-G14991

Source:

E. coli

Tag:

His

Molecular Weight:

22.7 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human VNN1 Protein (Recombinant His) (aa229-379) - LS-G14992

Source:

E. coli

Tag:

His

Molecular Weight:

18.1 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human VNN1 Protein (Recombinant His) (aa389-497) - LS-G14996

Source:

E. coli

Tag:

His

Molecular Weight:

13.5 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Mouse VNN1 Protein (Recombinant His) (aa390-503) - LS-G14998

Source:

E. coli

Tag:

His

Molecular Weight:

14.0 kDa

Price:

10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060

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