VNN1

Vanin 1

Vanin1 (pantetheinase) is an amidohydrolase that catalyzes the hydrolysis of D-pantetheine, permitting the recycling of pantothenate (vitamin B5) and the generation of an antioxidant metabolite, cysteamine. Vanin-1 is a glycosylphosphatidylinositol (GPI)-anchored molecule expressed by perivascular thymic stromal cells. Antibody against vanin-1 blocked thymus colonization by hematopoietic progenitor cells in both short- and long-term assays and interfered with lymphostromal cell adhesion. It is suggested that vanin-1 regulates late adhesion steps of thymus homing under physiologic, noninflammatory conditions. In addition the pantetheinase activity of the vanin-1 molecule is thought to be a major regulator of intestinal inflammation, acting through cysteamine release. Vanin1 (-/-) mice displayed a drastically reduced incidence of colorectal cancer.

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