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VNN1

Vanin 1

Vanin1 (pantetheinase) is an amidohydrolase that catalyzes the hydrolysis of D-pantetheine, permitting the recycling of pantothenate (vitamin B5) and the generation of an antioxidant metabolite, cysteamine. Vanin-1 is a glycosylphosphatidylinositol (GPI)-anchored molecule expressed by perivascular thymic stromal cells. Antibody against vanin-1 blocked thymus colonization by hematopoietic progenitor cells in both short- and long-term assays and interfered with lymphostromal cell adhesion. It is suggested that vanin-1 regulates late adhesion steps of thymus homing under physiologic, noninflammatory conditions. In addition the pantetheinase activity of the vanin-1 molecule is thought to be a major regulator of intestinal inflammation, acting through cysteamine release. Vanin1 (-/-) mice displayed a drastically reduced incidence of colorectal cancer.

Gene Name: Vanin 1
Synonyms: VNN1, HDLCQ8, Pantetheinase, Pantetheine hydrolase, Vanin-1, Tiff66, Vanin 1, Vannin 1
Target Sequences: NM_004666 NP_004657.2 O95497

Publications (1)

1
Plasma Proteomics Characteristics of Subclinical Vitamin E Deficiency of Dairy Cows During Early Lactation. Weidong Qian, Hongyi Yu, Cuiyu Zhang, Hongyou Zhang, Shixin Fu, Cheng Xia. Frontiers in veterinary science. 2021 December;8:723898. [Full Text Article] [PubMed:34957273] [PMC:PMC8703030] Related Antibodies: LS-C374585.

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Antibodies (64)
Primary (64)
VNN1 (64)
Human (38)
Mouse (22)
Rat (10)
Bovine (8)
Cow (8)
IHC (6)
IHC-P (5)
WB (57)
ELISA (7)
ICC (1)
IF (3)
IP (2)
Peptide-ELISA (1)
rabbit (63)
mouse (1)
Product Group
IHCPlus (2)
Ig (1)
IgG (11)
IgG2a,k (1)
monoclonal mc (1)
polyclonal pc (63)
4E11 (1)
APC (6)
APC Conjugated (6)
Biotin Conjugated (6)
Cy3 Conjugated (6)
Cy7 Conjugated (6)
FITC Conjugated (8)
HRP Conjugated (7)
PE Conjugated (6)
Preservative Free (1)
Unconjugated (19)
aa389-497 (9)
aa216-469 (8)
aa36-223 (8)
aa390-503 (8)
aa229-379 (7)
N-Terminus (1)
aa232-457 (1)
No (63)
Yes (1)
VNN1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
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VNN1 Mouse anti-Human Monoclonal (4E11) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Mouse Polyclonal (aa390-503) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
VNN1 Antibody - Immunohistochemistry (IHC) analysis of VNN1 antibody in paraffin-embedded human breast carcinoma tissue at 1:50, showing cytoplasm and membrane staining. Negative control (the right) using PBS instead of primary antibody. Secondary antibody is Goat Anti-Rabbit Ig.
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VNN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$356; 100 µl/$461
VNN1 Antibody - Western blot of VNN1 antibody.
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VNN1 Rabbit anti-Cow Polyclonal (aa216-469) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$328; 200 µl/$379; 500 µl/$547; 1 ml/$648; 2 ml/$883; 5 ml/$1,471
VNN1 Antibody - Immunohistochemistry image of paraffin-embedded human kidney tissue at a dilution of 1:100
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VNN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (HRP) Antibody
Mouse, Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (PE) Antibody
Mouse, Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (APC, Cy7) Antibody
Mouse, Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa36-223) (Cy3) Antibody
Mouse, Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
VNN1 Antibody - 1:100 staining human lymph carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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VNN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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VNN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$351
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa229-379) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
VNN1 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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VNN1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
VNN1 Antibody - Western blot of recombinant VNN1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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VNN1 Rabbit anti-Human Polyclonal (aa389-497) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
VNN1 Antibody - Immunofluorescence analysis of hepG2 cell  using VNN1 Polyclonal Antibody at dilution of 1:100
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VNN1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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VNN1 Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse
ELISA, IHC-P
Unconjugated, Preservative Free
100 µl/$412
VNN1 Antibody - All lanes: Anti-VNN1 Antibody (N-Term) at 1:2000 dilution Lane 1: A431 whole cell lysate Lane 2: HepG2 whole cell lysate Lane 3: human kidney lysate Lane 4: mouse kidney lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 57 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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VNN1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$393
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VNN1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
VNN1 Antibody - Sample (30 ug of whole cell lysate). A: H1299. 7.5% SDS PAGE. vanin-1 antibody. VNN1 antibody diluted at 1:1000.
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VNN1 Rabbit anti-Human Polyclonal (aa232-457) Antibody
Human
WB
Unconjugated
100 µl/$450
VNN1 Antibody - Western blot testing of human 1) SKOV3 and 2) HeLa lysate with VNN1 antibody at 0.5ug/ml. Expected molecular weight: ~56 kDa (unmodified) and ~70 kDa (glycosylated).
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VNN1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
VNN1 Antibody - Western blot - Anti-VNN1 Picoband Antibody
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VNN1 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).