VKORC1

Vitamin K Epoxide Reductase Complex, Subunit 1

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

VKORC1 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human VKORC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69817

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

9.7 kDa

Price:

20 µg/$1,107

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Human VKORC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85608

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.1 kDa

Price:

20 µg/$150

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Human VKORC1 Protein (Recombinant GST) (Full Length) - LS-G35119

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

44.6 kDa

Price:

10 µg/$479; 25 µg/$670

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VKORC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101853

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

18.1 kDa

Price:

100 µg/$494

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