VIL1 / Villin

villin 1

Epithelial cell-specific Ca2+-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination.

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Products

ELISA Kits (10)

Type

Custom (3)

Development Kit (1)

Sandwich (5)

Sandwich CLIA (1)

Target

VIL1 / Villin (10)

Reactivity

Human (6)

Mouse (1)

Chicken (1)

Pig (1)

Product Group

DevKit DuoPlus (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (7)

Antibody Pair and Standard (1)

Publications

No (10)

Sample Type

Cell Culture Supernatants (2)

Cell Lysates (2)

Plasma (5)

Serum (5)

Tissue Homogenates (4)

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Human VIL1 / Villin (Sandwich ELISA) ELISA Kit - LS-F13957

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Mouse VIL1 / Villin (Sandwich ELISA) ELISA Kit - LS-F13960

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human VIL1 / Villin (Sandwich ELISA) ELISA Kit - LS-F7927

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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DevKit DuoPlus Human VIL1 / Villin ELISA Development Kit - LS-F72044

Type:

Development Kit

Format:

Antibody Pair and Standard

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

500 Wells/$1,276; 1000 Wells/$1,903

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Chicken VIL1 / Villin (Custom ELISA) ELISA Kit - LS-F13958

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Pig VIL1 / Villin (Custom ELISA) ELISA Kit - LS-F13959

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine VIL1 / Villin (Custom ELISA) ELISA Kit - LS-F13961

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human VIL1 / Villin (Sandwich ELISA) ELISA Kit - LS-F21273

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human VIL1 / Villin (Sandwich ELISA) ELISA Kit - LS-F34923

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human VIL1 / Villin (CLIA) ELISA Kit - LS-F30391

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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