VHLL

von Hippel-Lindau tumor suppressor-like

Von Hippel-Lindau (VHL) tumor suppressor protein is a component of an E3 ubiquitin ligase complex that selectively ubiquitinates the alpha subunit of the hypoxia-inducible factor (HIF) transcription factor for proteasome-mediated degradation. Inactivation of VHL causes VHL disease and sporadic kidney cancer. This gene encodes a VHL homolog that lacks one of two key domains necessary for VHL function. This gene may contribute to the regulation of oxygen homeostasis and neovascularization during placenta development. This gene is intronless, and can also be interpreted as a retrotransposed pseudogene of the VHL locus located on chromosome 3. However, the protein is represented in this RefSeq due to evidence in PMID:14757845 that strongly suggests it is translated. The same publication also indicates that this protein binds HIF alpha but fails to recruit the E3 ubiquitin ligase complex, and it therefore functions as a dominant-negative VHL protein and a protector of HIF alpha.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

VHLL (3)

Publications

No (3)

Tag

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Human VHLL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G96544

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.6 kDa

Price:

20 µg/$150

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Human VHLL Protein (Recombinant His, N-Terminal) - LS-G144183

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

15.6 kDa

Price:

50 µg/$419

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VHLL Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99263

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.6 kDa

Price:

100 µg/$494

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