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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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VHL / Von Hippel Lindau

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene Name: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Synonyms: VHL, Elongin binding protein, HRCA1, RCA1, VHL1, Von Hippel-Lindau syndrome, Protein G7, PVHL
Target Sequences: NM_000551 NP_000542.1 P40337

Publications (2)

1
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH. Cancer research. 2006 66:3567-75. [PubMed:16585181]
2
MCM proteins are negative regulators of hypoxia-inducible factor 1. Hubbi ME, Luo W, Baek JH, Semenza GL. Molecular cell. 2011 42:700-12. (WB, IP; Human) [PubMed:21658608] [PMC:PMC3131976]

Viewing 1-25 of 63 items
VHL / Von Hippel Lindau Antibody - Anti-VHL / Von Hippel Lindau antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human VHL / Von Hippel Lindau
Rabbit, Mouse, Dog, Rat, Bat, Human, Monkey
ELISA, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
VHL / Von Hippel Lindau Antibody - Anti-VHL antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone Ig33] (IgG1)
Human
IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $425.00
VHL / Von Hippel Lindau Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-VHL mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI1E1] (IgG2b) to Human VHL / Von Hippel Lindau
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
VHL / Von Hippel Lindau Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-VHL mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI1E1] (IgG2b) to Human VHL / Von Hippel Lindau
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
VHL / Von Hippel Lindau Antibody - VHL Antibody (RB18668) IHC of formalin-fixed and paraffin-embedded mouse brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
50µl   $405.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200µl   $680.00
Select
Mouse Monoclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
50µl   $265.00
VHL / Von Hippel Lindau Antibody - Immunofluorescence of monoclonal antibody to VHL on HeLa cell . [antibody concentration 10 ug/ml]
Select
Mouse Monoclonal [clone 1G12] (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, IF, WB
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IF, IHC
Unconjugated
100µg   $435.00
VHL / Von Hippel Lindau Antibody - ICC/IF analysis of VHL in Hep3B. The cell was stained with VHL antibody (1:100).The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
Select
Mouse Monoclonal [clone AT82B10] (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, ICC, WB
Unconjugated
50µl   1mg/ml   $275.00; 100µl   1mg/ml   $345.00
VHL / Von Hippel Lindau Antibody - 1:200 staining mouse kidney tissue by IHC-P.
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
VHL / Von Hippel Lindau Antibody - Kidney 1
Select
Mouse Monoclonal [clone ABT-PVHL] (IgG) to Human VHL / Von Hippel Lindau
Human
IHC
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
VHL / Von Hippel Lindau Antibody - Immunohistochemistry analysis of paraffin-embedded human brain tissue, using VHL Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
50µg   1mg/ml   $265.00; 100µg   1mg/ml   $325.00
VHL / Von Hippel Lindau Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using VHL antibody.
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100µg   $305.00
VHL / Von Hippel Lindau Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using VHL Polyclonal Antibody at dilution of 1:40.
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
20µl   0.4mg/ml   $205.00; 60µl   0.4mg/ml   $235.00; 120µl   0.4mg/ml   $295.00; 200µl   0.4mg/ml   $395.00
VHL / Von Hippel Lindau Antibody - Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200.
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Mouse Monoclonal (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
100µl   $485.00
VHL / Von Hippel Lindau Antibody - Western blot of VHL pAb in extracts from 293(VHL overexpressed), 293(HA-VHL overexpressed), H1299 and C4-2 cells.
Select
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   1mg/ml   $345.00
Select
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
50µg   $845.00
Select
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Human
ELISA, IHC-P
Unconjugated
100µg   100µl   1mg/ml   $305.00

Viewing 1-25 of 63 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).