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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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VHL / Von Hippel Lindau

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene Name: von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
Synonyms: VHL, Elongin binding protein, HRCA1, RCA1, VHL1, Von Hippel-Lindau syndrome, Protein G7, PVHL
Target Sequences: NM_000551 NP_000542.1 P40337

Publications (2)

1
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Esteban MA, Tran MG, Harten SK, Hill P, Castellanos MC, Chandra A, Raval R, O'brien TS, Maxwell PH. Cancer research. 2006 66:3567-75. [PubMed:16585181]
2
MCM proteins are negative regulators of hypoxia-inducible factor 1. Hubbi ME, Luo W, Baek JH, Semenza GL. Molecular cell. 2011 42:700-12. (WB, IP; Human) [PubMed:21658608] [PMC:PMC3131976]

Filtered by: None
Target
VHL / Von Hippel Lindau (70)
Reactivity
Human (62)
Mouse (29)
Rat (25)
Bat (5)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Guinea pig (4)
Monkey (5)
Orangutan (3)
Pig (4)
Rabbit (1)
Application
IHC (20)
IHC-P (6)
WB (46)
Flo (2)
ELISA (34)
ICC (1)
IF (5)
IP (2)
Peptide-ELISA (3)
Host
rabbit (47)
mouse (19)
goat (2)
chicken (2)
Isotype
IgG (22)
IgG1 (1)
IgG1,k (10)
IgG2b (2)
IgG2b,k (4)
IgY (2)
Clonality
monoclonal mc (19)
polyclonal pc (51)
Clone
1G12 (1)
ABT-PVHL (1)
AT82B10 (1)
Ig33 (4)
OTI1E1 (2)
PAT82B10AT (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (7)
Carrier-free (1)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (3)
Unconjugated (42)
Epitope
aa6-175 (8)
aa43-71 (7)
aa27-76 (4)
10-90 aa (2)
C-Terminus (1)
N-Terminus (1)
aa1-213 (1)
aa167-179 (1)
aa181-210 (1)
internal region (1)
pSer68 (1)
Publications
No (70)
Showing 1-25 of 70 results

IHC-plus™ VHL / Von Hippel Lindau Antibody (aa167-179) LS-B10235
Goat Polyclonal to Human VHL / Von Hippel Lindau
Rabbit, Mouse, Dog, Rat, Bat, Human, Monkey
ELISA, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-VHL / Von Hippel Lindau antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
VHL antibody (0.01 ug/ml) staining of Human Ovary lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

VHL / Von Hippel Lindau Antibody (clone OTI1E1) LS-C174737
Mouse Monoclonal [clone OTI1E1] (IgG2b) to Human VHL / Von Hippel Lindau
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-VHL mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-VHL mouse monoclonal antibody.

VHL / Von Hippel Lindau Antibody (clone OTI1E1, Carrier-free) LS-C788118
Mouse Monoclonal [clone OTI1E1] (IgG2b) to Human VHL / Von Hippel Lindau
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-VHL mouse monoclonal antibody.
IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-VHL mouse monoclonal antibody.

VHL / Von Hippel Lindau Antibody (aa181-210) LS-C99277
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
VHL Antibody (RB18668) IHC of formalin-fixed and paraffin-embedded mouse brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot of VHL antibody in HepG2 cell line lysates (35 ug/lane). VHL (arrow) was detected using the purified antibody.

VHL / Von Hippel Lindau Antibody (aa43-71, HRP) LS-C550287
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200µl  $680.00

VHL / Von Hippel Lindau Antibody (aa43-71, Biotin) LS-C530201
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Human
ELISA, Flo, IF, IHC, WB
Biotin Conjugated
200µl  $680.00

IHC-plus™ VHL / Von Hippel Lindau Antibody (clone Ig33) LS-B6316
Mouse Monoclonal [clone Ig33] (IgG1)
Human
IHC, IHC-P, IP, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-VHL antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunohistochemical staining using von Hippel-Lindau antibody on formalin fixed, paraffin embedded human kidney tissue.

VHL / Von Hippel Lindau Antibody LS-C747151
Mouse Monoclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
50µl  $265.00

VHL / Von Hippel Lindau Antibody (clone 1G12) LS-C198428
Mouse Monoclonal [clone 1G12] (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, IF, WB
Unconjugated
100µg  $365.00
Immunofluorescence of monoclonal antibody to VHL on HeLa cell . [antibody concentration 10 ug/ml]
Western Blot analysis of VHL expression in transfected 293T cell line by VHL monoclonal antibody (M01), clone 1G12.Lane 1: VHL transfected lysate(19.7 KDa).Lane 2: Non-transfected lysate.

VHL / Von Hippel Lindau Antibody LS-C661551
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IF, IHC
Unconjugated
100µg  $465.00

VHL / Von Hippel Lindau Antibody LS-C661549
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IF, IHC
Unconjugated
100µg  $435.00

VHL / Von Hippel Lindau Antibody (clone AT82B10) LS-C755589
Mouse Monoclonal [clone AT82B10] (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, ICC, WB
Unconjugated
50µl 1mg/ml  $275.00; 100µl 1mg/ml  $345.00
ICC/IF analysis of VHL in Hep3B. The cell was stained with VHL antibody (1:100).The secondary antibody (green) was used Alexa Fluor 488. DAPI was stained the cell nucleus (blue).
The cell lysates (40ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human VHL antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: HepG2 cell lysate Lane 2.: HeLa cell lysate Lane 3.: Raji cell lysate Lane 4.: Jurkat cell lysate Lane 5.: A549 cell lysate Lane 6.: MCF7 cell lysate Lane 7.: PC3 cell lysate

VHL / Von Hippel Lindau Antibody LS-C808647
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

VHL / Von Hippel Lindau Antibody (clone ABT-PVHL) LS-C744561
Mouse Monoclonal [clone ABT-PVHL] (IgG) to Human VHL / Von Hippel Lindau
Human
IHC
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Kidney 1
Kidney 2

VHL / Von Hippel Lindau Antibody (10-90 aa) LS-C381704
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

VHL / Von Hippel Lindau Antibody (10-90 aa) LS-C386647
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

VHL / Von Hippel Lindau Antibody LS-C743308
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
50µg 1mg/ml  $265.00; 100µg 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using VHL Antibody. The picture on the right is blocked with the synthesized peptide.

VHL / Von Hippel Lindau Antibody (clone PAT82B10AT) LS-C760803
Mouse Monoclonal [clone PAT82B10AT] (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
5µg  $195.00; 20µg  $255.00; 100µg  $475.00

VHL / Von Hippel Lindau Antibody LS-C11035
Mouse Monoclonal (IgG2b,k) to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
100µl  $485.00

VHL / Von Hippel Lindau Antibody LS-C192272
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $385.00
Western blot of VHL pAb in extracts from 293(VHL overexpressed), 293(HA-VHL overexpressed), H1299 and C4-2 cells.

VHL / Von Hippel Lindau Antibody LS-C401115
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using VHL Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human thyroid cancer using VHL Polyclonal Antibody at dilution of 1:40.

VHL / Von Hippel Lindau Antibody LS-C404380
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Human
ELISA, IHC
Unconjugated
20µl 0.2mg/ml  $205.00; 60µl 0.2mg/ml  $235.00; 120µl 0.2mg/ml  $295.00; 200µl 0.2mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human thyroid cancer using VHL Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human thyroid cancer using VHL Polyclonal Antibody at dilution of 1:40.

VHL / Von Hippel Lindau Antibody (phospho-Ser68) LS-C291211
Rabbit Polyclonal (IgG) to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
IHC, Peptide-ELISA
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00

VHL / Von Hippel Lindau Antibody LS-C413722
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg 1mg/ml  $345.00

VHL / Von Hippel Lindau Antibody LS-C11034
Rabbit Polyclonal to Human VHL / Von Hippel Lindau
Human
ELISA, WB
Unconjugated
50µg  $845.00
Showing 1-25 of 70 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).