VHL / Von Hippel Lindau

von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase

Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

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Products

Proteins (10)

Type

Over-Expression Lysate (4)

Recombinant (6)

Target

VHL / Von Hippel Lindau (10)

Publications

No (10)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (4)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human VHL / Von Hippel Lindau Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79583

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.5 kDa

Price:

20 µg/$150

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Human VHL / Von Hippel Lindau Protein (Recombinant His) - LS-G3595

Source:

E. coli

Tag:

His

Price:

100 µg/$317; 500 µg/$526; 20 µg/$245

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Human VHL / Von Hippel Lindau Protein (Recombinant GST, N-terminus) (Full Length) - LS-G30875

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Molecular Weight:

46.1 kDa

Price:

2 µg/$439

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Human VHL / Von Hippel Lindau Protein (Recombinant 6His, N-terminus) (Full Length) - LS-G137134

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.2 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat VHL / Von Hippel Lindau Protein (Recombinant His, N-terminus) (aa6-175) - LS-G26027

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

23.3 kDa

Price:

10 µg/$284; 50 µg/$462; 200 µg/$922; 1 mg/$2,042; 5 mg/$3,221; 2 mg/$2,231

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Human VHL / Von Hippel Lindau Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67338

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$1,107

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Human VHL / Von Hippel Lindau Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79581

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

20 µg/$150

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VHL / Von Hippel Lindau Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103751

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

19.5 kDa

Price:

100 µg/$494

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Human VHL / Von Hippel Lindau Protein (Recombinant His, N-Terminal) - LS-G144186

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

24 kDa

Price:

50 µg/$419

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VHL / Von Hippel Lindau Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99073

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

24 kDa

Price:

100 µg/$494

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