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VEGFC

vascular endothelial growth factor C

Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Gene Name:	vascular endothelial growth factor C
Family/Subfamily:	PDGF , not assigned-PDGF
Synonyms:	VEGFC, Flt4-L, FLT4 ligand DHM, VEGF-C, VRP, Flt4 ligand
Target Sequences:	NM_005429 NP_005420.1 P49767

Publications (2)

MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer. Hirata H, Hinoda Y, Ueno K, Shahryari V, Tabatabai ZL, Dahiya R. Carcinogenesis. 2012 33:41-8. [PubMed:22049531] [PMC:PMC3276333]

Peripheral Nerve Single-Cell Analysis Identifies Mesenchymal Ligands that Promote Axonal Growth. Jeremy S Toma, Konstantina Karamboulas, Matthew J Carr, Adelaida Kolaj, Scott A Yuzwa, Neemat Mahmud, Mekayla A Storer, David R Kaplan, Freda D Miller. eNeuro. 2020 May;7: [Full Text Article] [PubMed:32349983] [PMC:PMC7294463]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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