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VEGFB

vascular endothelial growth factor B

VEGFB is a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified.

Gene Name: vascular endothelial growth factor B
Family/Subfamily: PDGF , not assigned-PDGF
Synonyms: VEGFB, VRF, VEGF-B, VEGF-related factor, VEGFL
Target Sequences: NM_003377 NP_003368.1 P49765

Publications (1)

1
Estrogen-regulated miRNA-27b is altered by bisphenol A in endometrial stromal cells. Reed BG, Babayev SN, Chen LX, Carr BR, Word RA, Jimenez PT. Reproduction (Cambridge, England). 2018 September;pii: REP-18-0041. [Full Text Article] [PubMed:30328349] [PMC:PMC6215928]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).