VCP

valosin containing protein

Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

VCP (10)

Publications

No (10)

Tag

6His, C-terminus (2)

GST (2)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (4)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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Human VCP Protein (Recombinant 6His, C-terminus) (Ala2-Asn589) - LS-G39662

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66.4kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353

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Human VCP Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G60503

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VCP Protein (Recombinant His) (aa125-371) - LS-G24982

Source:

E. coli

Tag:

His

Molecular Weight:

31.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human VCP Protein (Recombinant GST, N-terminus) (aa221-310) - LS-G60501

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VCP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87302

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.1 kDa

Price:

20 µg/$150

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Human VCP Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70517

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.1 kDa

Price:

20 µg/$1,107

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Human VCP Protein (Recombinant GST) (Full Length) - LS-G30867

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

90.42 kDa

Price:

10 µg/$479; 25 µg/$670

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Human VCP Protein (Recombinant GST) (Full Length) - LS-G30866

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

115.7 kDa

Price:

10 µg/$479; 25 µg/$670

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Human VCP Protein (Recombinant 6His, C-terminus) (Ala2-Asn589) - LS-G140454

Source:

E. coli

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

66.4 kDa

Price:

10 µg/$344; 50 µg/$584

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VCP Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100980

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.1 kDa

Price:

100 µg/$494

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