VAV1 / VAV

vav 1 guanine nucleotide exchange factor

VAV1 / VAV is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

VAV1 / VAV (7)

Publications

No (7)

Tag

GST, N-terminus (1)

His (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human VAV1 / VAV Protein (Recombinant His-GST) (aa426-696) - LS-G24695

Source:

E. coli

Tag:

His-GST

Molecular Weight:

61.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human VAV1 / VAV Protein (Recombinant GST, N-terminus) (aa681-790) - LS-G60499

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human VAV1 / VAV Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67323

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.1 kDa

Price:

20 µg/$1,107

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Human VAV1 / VAV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79546

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.1 kDa

Price:

20 µg/$215

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Mouse VAV1 / VAV Protein (Recombinant His-T7) (aa565-795) - LS-G24696

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.2 kDa

Price:

10 µg/$279; 50 µg/$427; 100 µg/$682; 200 µg/$852; 1 mg/$1,948; 500 µg/$1,493; 5 mg/$2,976; 2 mg/$2,134

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Human VAV1 / VAV Protein (Recombinant His) - LS-G2644

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$739; 4 µg/$261

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VAV1 / VAV Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115985

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

98.1 kDa

Price:

100 µg/$710

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