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VAMP2 / VAMP-2
vesicle-associated membrane protein 2 (synaptobrevin 2)
VAMP2 / VAMP-2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
| Gene Name: | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| Family/Subfamily: | Synaptobrevin |
| Synonyms: | VAMP2, SYB2, Synaptobrevin 2, VAMP-2, Synaptobrevin-2 |
| Target Sequences: | NM_014232 NP_055047.2 P63027 |
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