USP5

ubiquitin specific peptidase 5 (isopeptidase T)

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

USP5 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His,C-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

HEK 293 Cells (3)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human USP5 Protein (Recombinant His,C-terminus) (Met1-Ser835) - LS-G137954

Source:

Insect Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

94.7 kDa

Price:

100 µg/$661

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USP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117308

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.1 kDa

Price:

100 µg/$494

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USP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G119260

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

100 µg/$710

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Human USP5 Protein (Recombinant GST) (Full Length) - LS-G31062

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

122.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human USP5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67257

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.1 kDa

Price:

20 µg/$1,107

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Human USP5 Protein (Recombinant GST, N-terminus) (aa71-180) - LS-G60646

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human USP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79433

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

20 µg/$215

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Human USP5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79434

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

93.1 kDa

Price:

20 µg/$150

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