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USP5

ubiquitin specific peptidase 5 (isopeptidase T)

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Gene Name: ubiquitin specific peptidase 5 (isopeptidase T)
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP5, Deubiquitinating enzyme 5, ISOT, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin isopeptidase T, Ubiquitin thioesterase 5
Target Sequences: NM_003481 NP_003472.2 P45974

Publications (1)

1
Functional analysis of C-type lysozyme in penaeid shrimp. Kaizu A, Fagutao FF, Kondo H, Aoki T, Hirono I. The Journal of biological chemistry. 2011 286:44344-9. [PubMed:22069322] [PMC:PMC3247961]

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Products
Antibodies (37)
Primary (37)
USP5 (37)
Human (34)
Mouse (3)
Rat (9)
Dog (6)
Monkey (8)
IHC (14)
IHC-P (6)
WB (30)
ELISA (15)
IF (3)
IP (4)
Peptide-ELISA (1)
rabbit (22)
mouse (15)
IgG (17)
IgG1 (7)
IgG1,k (1)
IgG2a (6)
IgG2a,k (1)
monoclonal mc (15)
polyclonal pc (22)
1340CT704.170.140 (1)
2C8 (1)
OTI1A8 (2)
OTI1F8 (2)
OTI1F9 (2)
OTI2E3 (2)
OTI2F5 (2)
OTI2H5 (2)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
Carrier-free (6)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (29)
aa484-514 (7)
aa375-425 (2)
aa2-223 (1)
aa204-217 (1)
aa75-125 (1)
No (37)
USP5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (OTI2F5) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
USP5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI2F5) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
USP5 Antibody - IHC of paraffin-embedded Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (OTI2E3) Antibody
Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
USP5 Antibody - IHC of paraffin-embedded Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E3) Antibody
Dog, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
USP5 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (OTI1F8) Antibody
Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
USP5 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI1F8) Antibody
Dog, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
USP5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI2H5) Antibody
Dog, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
USP5 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (OTI1A8) Antibody
IHC, IHC-P, WB
Unconjugated
100 µl/$434
USP5 Antibody - Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-USP5 mouse monoclonal antibody. (Dilution 1:50).
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USP5 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A8) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
USP5 Antibody - Detection of Human USP5/IsoT by IHC-IF. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus 555 (A120-501E) used at a dilution of 1:100.
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USP5 Rabbit anti-Human Polyclonal (aa375-425) Antibody
Human
IF, IHC
Unconjugated
1 µg/$295; 100 µl/$532
USP5 Antibody
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USP5 Rabbit anti-Human Polyclonal (aa2-223) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
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USP5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$341
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USP5 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$341
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USP5 Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$361
USP5 Antibody - Detection limit for recombinant GST tagged USP5 is approximately 0.03 ng/ml as a capture antibody.
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USP5 Mouse anti-Human Monoclonal (2C8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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USP5 Rabbit anti-Human Polyclonal (aa484-514) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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USP5 Rabbit anti-Human Polyclonal (aa484-514) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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USP5 Rabbit anti-Human Polyclonal (aa484-514) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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USP5 Rabbit anti-Human Polyclonal (aa484-514) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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USP5 Rabbit anti-Human Polyclonal (aa484-514) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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USP5 Rabbit anti-Human Polyclonal (aa484-514) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
USP5 Antibody - Detection of Human USP5/IsoT by Immunohistochemistry. Sample: FFPE section of human colon carcinoma. Antibody: Affinity purified rabbit anti-USP5/IsoT used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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USP5 Rabbit anti-Human Polyclonal (aa375-425) Antibody
Human
IHC, IP
Unconjugated
10 µg/$295; 100 µl/$514
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USP5 Rabbit anti-Rat Polyclonal Antibody
Rat
IHC, WB
Unconjugated
100 µg/$1,056
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USP5 Rabbit anti-Human Polyclonal (aa75-125) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
USP5 Antibody - Western blot analysis of extracts of A549 cells using UBP5 antibody. The lane on the left was treated with blocking peptide.
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USP5 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).