Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a negative regulator of histone H2B (H2BK120ub1) ubiquitination.
Gene Name: | Ubiquitin Specific Peptidase 44 |
Synonyms: | USP44, Ubiquitin specific protease 44, Ubiquitin thioesterase 44, Ubiquitin thiolesterase 44, Deubiquitinating enzyme 44 |
Target Sequences: | NM_032147 NP_115523.2 Q9H0E7 |
If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.