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USP4
ubiquitin specific peptidase 4 (proto-oncogene)
Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.
| Gene Name: | ubiquitin specific peptidase 4 (proto-oncogene) |
| Family/Subfamily: | Protease , Cysteine C19 |
| Synonyms: | USP4, Deubiquitinating enzyme 4, Unph, Ubiquitin thiolesterase 4, Ubiquitin thioesterase 4, Ubiquitin-specific protease 4, UNP |
| Target Sequences: | NM_003363 NP_003354.2 Q13107 |
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