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USP22

ubiquitin specific peptidase 22

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Gene Name: ubiquitin specific peptidase 22
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP22, KIAA1064, Ubiquitin thiolesterase 22, USP3L, Ubiquitin specific protease 22, Ubiquitin thioesterase 22, Deubiquitinating enzyme 22, KIAA1063
Target Sequences: AB028986 BAA83015.1 Q9UPT9

Publications (1)

1
Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer. Xiao Yuan, Hao Wang, Aman Xu, Xingyang Zhu, Yanqing Zhan, Wenbin Wang. Oncology letters. 2019 Nov;18:5567-5576. [Full Text Article] [PubMed:31612065] [PMC:PMC6781658] Related Antibodies: LS-C99567.

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Proteins (3)
Over-Expression Lysate (2)
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USP22 (3)
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His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
E. coli (1)
HEK 293 Cells (1)
USP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.8 kDa
100 µg/$710
USP22 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.8 kDa
20 µg/$215
USP22 Protein
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E. coli
His, N-Terminal
59.8 kDa
50 µg/$419
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).