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USP2

ubiquitin specific peptidase 2

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.

Gene Name: ubiquitin specific peptidase 2
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP2, Deubiquitinating enzyme 2, Ubiquitin specific peptidase 2, Ubiquitin specific protease 9, USP9, Ubiquitin specific protease 12, Ubiquitin specific protease 2, Ubiquitin thioesterase 2, UBP41
Target Sequences: NM_004205 NP_004196.4 O75604

Publications (2)

1
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. Stevenson LF, Sparks A, Allende-Vega N, Xirodimas DP, Lane DP, Saville MK. The EMBO journal. 2007 26:976-86. [PubMed:17290220] [PMC:PMC1852834] Related Antibodies: LS-C99527.
2
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2. Oberfeld B, Ruffieux-Daidi D, Vitagliano JJ, Pos KM, Verrey F, Staub O. American journal of physiology. Renal physiology. 2011 301:F189-96. [PubMed:21478478] Related Antibodies: LS-C99529.

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USP2 (7)
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His, N-Terminal (2)
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Human (4)
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293T Cells (2)
E. coli (2)
HEK 293 Cells (3)
USP2 Protein - Recombinant Ubiquitin Specific Peptidase 2 (USP2) by SDS-PAGE
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E. coli
His, N-Terminal
26.1kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
USP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
67.9 kDa
20 µg/$150
USP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$150
USP2 Protein - Purified recombinant protein USP2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
20 µg/$1,107
USP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.1 kDa
100 µg/$494
USP2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
67.9 kDa
100 µg/$494
USP2 Protein - Recombinant Ubiquitin Specific Peptidase 2 (USP2) by SDS-PAGE
Select
E. coli
His, N-Terminal
26.4kDa
10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).