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USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Gene Name: ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Family/Subfamily: Protease , Cysteine C19
Synonyms: USP14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin thiolesterase 14, TGT, TRNA-guanine transglycosylase, Ubiquitin specific protease 14
Target Sequences: NM_005151 NP_005142.1 P54578

☰ Filters
Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
USP14 (10)
No (10)
6His, N-terminus (2)
GST (1)
GST, N-terminus (1)
His (3)
Myc-DDK (Flag) (3)
Human (9)
293T Cells (1)
E. coli (5)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
USP14 Protein - Recombinant Ubiquitin Specific Peptidase 14 By SDS-PAGE
Select
E. coli
His
59.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
USP14 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
100 µg/$494
USP14 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
His
60.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
USP14 Protein - 12.5% SDS-PAGE of human USP14 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
79.97 kDa
10 µg/$479; 25 µg/$670
USP14 Protein - Purified recombinant protein USP14 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$1,107
USP14 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
55.9 kDa
20 µg/$150
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.45kD
10 µg/$262; 50 µg/$405; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.5 kDa
10 µg/$350; 50 µg/$490
Viewing 1-10 of 10 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).