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USP14

ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)

Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).

Gene Name:	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
Family/Subfamily:	Protease , Cysteine C19
Synonyms:	USP14, Deubiquitinating enzyme 14, Ubiquitin thioesterase 14, Ubiquitin thiolesterase 14, TGT, TRNA-guanine transglycosylase, Ubiquitin specific protease 14
Target Sequences:	NM_005151 NP_005142.1 P54578

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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