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B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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URP2 / FERMT3
fermitin family member 3
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.
| Gene Name: | fermitin family member 3 |
| Synonyms: | FERMT3, Fermitin family member 3, Fermitin family homolog 3, Kindlin-3, KIND3, Mig-2, MIG2B, UNC-112 related protein 2, Unc-112-related protein 2, UNC112C, Kindlin 3, MIG2-like protein, URP2, URP2SF |
| Target Sequences: | NM_031471 NP_113659.3 Q86UX7 |
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