URI1 / NNX3

URI1, prefoldin-like chaperone

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

URI1 / NNX3 (5)

Publications

No (5)

Tag

GST (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human URI1 / NNX3 Protein (Recombinant GST) - LS-G132126

Tag:

GST

Molecular Weight:

37.29kDa

Price:

10 µg/$479; 25 µg/$670

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URI1 / NNX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117089

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

100 µg/$710

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Human URI1 / NNX3 Protein (Recombinant GST) (Full Length) - LS-G31297

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

82 kDa

Price:

10 µg/$479; 25 µg/$670

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Human URI1 / NNX3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68490

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$1,107

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Human URI1 / NNX3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82303

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

59.7 kDa

Price:

20 µg/$215

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