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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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URI1 / NNX3

URI1, prefoldin-like chaperone

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Gene Name: URI1, prefoldin-like chaperone
Synonyms: URI1, C19orf2, NNX3, PPP1R19, RMP, RPB5-mediating protein, URI, Protein NNX3, URI1, prefoldin-like chaperone
Target Sequences: NM_003796 NP_003787.2 O94763


URI1 / NNX3 Antibody - The anti-RMP antibody is used in Western blot to detect RMP in T47D (left) and Jurkat (right) cell line lysates.
Select
Rabbit Polyclonal to Human URI1 / NNX3
Human
WB
Unconjugated
400µl   $325.00
URI1 / NNX3 Antibody - C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
URI1 / NNX3 Antibody - C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl   1mg/ml   $385.00
URI1 / NNX3 Antibody - C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl   1mg/ml   $385.00
URI1 / NNX3 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
URI1 / NNX3 Antibody - Western blot analysis of the lysates from K562 cells using RMP antibody.
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Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal to Human URI1 / NNX3
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $345.00
URI1 / NNX3 Antibody - Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IP, WB
Unconjugated
100µl   0.2mg/ml   $405.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
100µl   $530.00
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
URI1 / NNX3 Antibody - Western blot analysis of extracts of T47D cells.
Select
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
100µl   $295.00; 200µl   $385.00
URI1 / NNX3 Antibody - Western blot analysis of URI1 expression in Jurkat (A); Raw264.7 (B); PC12 (C) whole cell lysates.
Select
Rabbit Polyclonal to Human URI1 / NNX3
Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $245.00
Select
Mouse Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
50µg   $560.00
Viewing 1-25 of 29 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).