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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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URI1 / NNX3

URI1, prefoldin-like chaperone

Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination.

Gene Name: URI1, prefoldin-like chaperone
Synonyms: URI1, C19orf2, NNX3, PPP1R19, RMP, RPB5-mediating protein, URI, Protein NNX3, URI1, prefoldin-like chaperone
Target Sequences: NM_003796 NP_003787.2 O94763

Filtered by: None
Target
URI1 / NNX3 (28)
Reactivity
Human (28)
Mouse (4)
Rat (3)
Chimpanzee (3)
Gibbon (3)
Horse (4)
Monkey (5)
Orangutan (3)
Rabbit (4)
Application
IHC (5)
IHC-P (1)
WB (25)
ELISA (9)
IF (1)
IP (3)
Peptide-ELISA (2)
Host
rabbit (27)
mouse (1)
Isotype
IgG (21)
Clonality
polyclonal pc (28)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (16)
Epitope
aa347-376 (8)
aa359-408 (4)
C-Terminus (2)
390-470 aa, C-terminal (1)
aa122-171 (1)
aa181-226 (1)
aa350-400 (1)
aa415-464 (1)
aa458-508 (1)
Publications
No (28)
Showing 1-25 of 28 results

URI1 / NNX3 Antibody (aa359-408) LS-C111293
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

URI1 / NNX3 Antibody (aa359-408, HRP) LS-C454197
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

URI1 / NNX3 Antibody (aa359-408, Biotin) LS-C454195
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

URI1 / NNX3 Antibody (aa359-408, FITC) LS-C454196
Rabbit Polyclonal to Human URI1 / NNX3
Rabbit, Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100µl 1mg/ml  $385.00
C19orf2 / NNX3 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

URI1 / NNX3 Antibody (aa347-376) LS-C97594
Rabbit Polyclonal to Human URI1 / NNX3
Human
WB
Unconjugated
400µl  $325.00
The anti-RMP antibody is used in Western blot to detect RMP in T47D (left) and Jurkat (right) cell line lysates.

URI1 / NNX3 Antibody LS-C807327
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Immunofluorescence Image

URI1 / NNX3 Antibody (390-470 aa, C-terminal) LS-C385920
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

URI1 / NNX3 Antibody (aa415-464) LS-C291381
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00

URI1 / NNX3 Antibody (aa122-171) LS-C200606
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Western blot analysis of the lysates from K562 cells using RMP antibody.

URI1 / NNX3 Antibody (aa181-226) LS-C313935
Rabbit Polyclonal to Human URI1 / NNX3
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl  $345.00

URI1 / NNX3 Antibody LS-C675056
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:300 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

URI1 / NNX3 Antibody (aa347-376) LS-C330637
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
Unconjugated
200µl  $590.00

URI1 / NNX3 Antibody (aa347-376, Biotin) LS-C220588
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
Biotin Conjugated
200µl  $740.00

URI1 / NNX3 Antibody (aa347-376, FITC) LS-C220590
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
FITC Conjugated
200µl  $740.00

URI1 / NNX3 Antibody (aa347-376, AP) LS-C220585
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
AP Conjugated
200µl  $740.00

URI1 / NNX3 Antibody (aa347-376, APC) LS-C220587
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
APC Conjugated
200µl  $740.00

URI1 / NNX3 Antibody (aa347-376, Azide-free, HRP) LS-C220589
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl  $740.00

URI1 / NNX3 Antibody (aa347-376, PE) LS-C220591
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
ELISA, WB
PE Conjugated
200µl  $740.00

URI1 / NNX3 Antibody (C-Terminus) LS-C144147
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Mouse, Rat, Human, Monkey
IP, WB
Unconjugated
100µl  $530.00

URI1 / NNX3 Antibody (aa458-508) LS-C287985
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00

URI1 / NNX3 Antibody (aa350-400) LS-C287984
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00

URI1 / NNX3 Antibody LS-C771648
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

URI1 / NNX3 Antibody (C-Terminus) LS-C353085
Rabbit Polyclonal to Human URI1 / NNX3
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of URI1 expression in Jurkat (A); Raw264.7 (B); PC12 (C) whole cell lysates.

URI1 / NNX3 Antibody LS-C408760
Rabbit Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of T47D cells.

URI1 / NNX3 Antibody LS-C306622
Mouse Polyclonal (IgG) to Human URI1 / NNX3
Human
WB
Unconjugated
50µg  $560.00
Showing 1-25 of 28 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).