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URAT1 / SLC22A12
solute carrier family 22 (organic anion/urate transporter), member 12
URAT1 / SLC22A12 is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants.
| Gene Name: | solute carrier family 22 (organic anion/urate transporter), member 12 |
| Family/Subfamily: | Transporter , Organic cation transporter |
| Synonyms: | SLC22A12, OATL4, RST, OAT4L, Urate transporter 1, Urate anion exchanger 1, Renal-specific transporter, URAT1 |
| Target Sequences: | NM_144585 NP_653186.2 Q96S37 |
Publications (1)
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