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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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UNG / Uracil DNA Glycosylase
uracil-DNA glycosylase
UNG / Uracil DNA Glycosylase is one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases.
| Gene Name: | uracil-DNA glycosylase |
| Synonyms: | UNG, DGU, HIGM4, HIGM5, Uracil-DNA glycosylase, UNG1, UNG2, UDG, UNG15 |
| Target Sequences: | NM_003362 NP_003353.1 P13051 |
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