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UNC84B / SUN2

Sad1 and UNC84 domain containing 2

Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5.

Gene Name: Sad1 and UNC84 domain containing 2
Synonyms: SUN2, FRIGG, Nuclear envelope protein, Protein unc-84 homolog B, Sad1 unc-84 domain protein 2, Sad1/unc-84 protein-like 2, Unc-84 homolog B, Unc-84 homolog B (C. elegans), KIAA0668, Rab5-interacting protein, RAB5IP, UNC84B
Target Sequences: NM_015374 NP_056189.1 Q9UH99

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
UNC84B / SUN2 (4)
No (4)
GST (1)
Myc-DDK (Flag) (3)
Human (3)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
UNC84B / SUN2 Protein - 12.5% SDS-PAGE of human UNC84B stained with Coomassie Blue
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Wheat Germ Extract
GST
105.27 kDa
10 µg/$479; 25 µg/$670
UNC84B / SUN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
80.1 kDa
100 µg/$710
UNC84B / SUN2 Protein - Purified recombinant protein SUN2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
80.1 kDa
20 µg/$1,107
UNC84B / SUN2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
80.1 kDa
20 µg/$215
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).