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UNC5H3 / UNC5C
unc-5 homolog C (C. elegans)
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
| Gene Name: | unc-5 homolog C (C. elegans) |
| Synonyms: | UNC5C, Unc-5 homolog 3, UNC5H3, Netrin receptor UNC5C, Protein unc-5 homolog 3, Protein unc-5 homolog C, Unc-5 homolog C (C. elegans), Unc5 (C.elegans homolog) c |
| Target Sequences: | NM_003728 NP_003719.3 O95185 |
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