ULK2

unc-51 like autophagy activating kinase 2

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.

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Proteins (5)

Type

Over-Expression Lysate (4)

Recombinant (1)

Target

ULK2 (5)

Publications

No (5)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (4)

Species

Human (3)

Source

293T Cells (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human ULK2 Protein (Recombinant GST, N-terminus) (aa743-843) - LS-G61226

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ULK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88205

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.5 kDa

Price:

20 µg/$215

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Human ULK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88206

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.5 kDa

Price:

20 µg/$150

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ULK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101247

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.5 kDa

Price:

100 µg/$494

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ULK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126044

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

112.5 kDa

Price:

100 µg/$710

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