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ULBP2 / RAET1H

UL16 binding protein 2

Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.

Gene Name: UL16 binding protein 2
Synonyms: ULBP2, ALCAN-alpha, N2DL-2, RAET1H, UL16-binding protein 2, N2DL2, NKG2D ligand 2, NKG2DL2, UL16 binding protein 2
Target Sequences: NM_025217 NP_079493.1 Q9BZM5

Publications (1)

1
Human Metapneumovirus Escapes NK Cell Recognition through the Downregulation of Stress-Induced Ligands for NKG2D. Mohammad Diab, Dominik Schmiedel, Einat Seidel, Eran Bacharach, Ofer Mandelboim. Viruses. 2020 July;12: [Full Text Article] [PubMed:32698530] [PMC:PMC7412239] Related Antibodies: LS-C409800.

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Antibodies (25)
Primary (25)
ULBP2 / RAET1H (25)
Human (24)
Mouse (2)
Rat (2)
IHC (3)
IHC-P (3)
WB (19)
ELISA (13)
IF (1)
rabbit (25)
IgG (11)
polyclonal pc (25)
APC (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (2)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Preservative Free (1)
Unconjugated (13)
aa2-246 (8)
aa88-116 (7)
aa26-216 (1)
No (24)
Yes (1)
ULBP2 / RAET1H Antibody - Immunohistochemistry of paraffin-embedded human duodenum using antibody at 1:100 dilution.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa26-216) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
ULBP2 / RAET1H Antibody - Western blot analysis of extract of various cells.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
20 µl/$271; 100 µl/$412
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
20 µl/$271; 100 µl/$412
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA
Unconjugated, Preservative Free
100 µl/$412
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) Antibody
Human
WB
Unconjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$597; 2 ml/$826; 5 ml/$1,352
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$351; 200 µl/$411; 500 µl/$618; 1 ml/$774; 2 ml/$1,010; 5 ml/$1,757
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$329; 200 µl/$381; 500 µl/$550; 1 ml/$654; 2 ml/$890; 5 ml/$1,487
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$362; 200 µl/$427; 500 µl/$666; 1 ml/$826; 2 ml/$1,067; 5 ml/$1,892
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$535; 200 µl/$714; 500 µl/$1,236; 1 ml/$1,545; 2 ml/$2,163; 5 ml/$4,053
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
ULBP2 / RAET1H Antibody - Western blot of ULBP2 / RAET1H antibody.
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa2-246) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$427; 200 µl/$519; 500 µl/$916; 1 ml/$1,084; 2 ml/$1,441; 5 ml/$2,703
ULBP2 / RAET1H Antibody - ULBP2 Antibody western blot of U251 cell line lysates (35 ug/lane). The ULBP2 antibody detected the ULBP2 protein (arrow).
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ULBP2 / RAET1H Rabbit anti-Human Polyclonal (aa88-116) Antibody
Human
WB
Unconjugated
400 µl/$393
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).