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UIMC1 / RAP80
ubiquitin interaction motif containing 1
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
| Gene Name: | ubiquitin interaction motif containing 1 |
| Synonyms: | UIMC1, BRCA1-A complex subunit RAP80, Receptor associated protein 80, RAP80, RXRIP110, X2HRIP110, Receptor-associated protein 80 |
| Target Sequences: | NM_016290 NP_057374.3 Q96RL1 |
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