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UCP2

uncoupling protein 2 (mitochondrial, proton carrier)

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.

Gene Name: uncoupling protein 2 (mitochondrial, proton carrier)
Family/Subfamily: Transporter , Mitochondrial carrier
Synonyms: UCP2, BMIQ4, UCP 2, Uncoupling protein 2, UCPH, SLC25A8
Target Sequences: NM_003355 NP_003346.2 P55851

Publications (8)

1
Uncoupling protein 2 expression in colon cancer and its clinical significance. Kuai Xiao Yi, Li Zhengyang, Steffi. World journal of gastroenterology : WJG. 2010 16:5773-8. (IHC-Fr; Human) [Full Text Article] [PubMed:21128330] [PMC:PMC2997996]
2
Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells. Chen Y, Li ZY, Yang Y, Zhang HJ. World journal of gastroenterology : WJG. 2012 18:3451-7. (ICC, WB; Human) [Full Text Article] [PubMed:22807616] [PMC:PMC3396199]
3
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM. Free radical biology & medicine. 2012 53:216-29. (WB; Human) [Full Text Article] [PubMed:22583703] [PMC:PMC3527085]
4
AKI after conditional and kidney-specific knockdown of stanniocalcin-1. Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D. Journal of the American Society of Nephrology : JASN. 2014 25:2303-15. (IHC, WB; Mouse) [Full Text Article] [PubMed:24700878] [PMC:PMC4178431] Related Antibodies: LS-B3249.
5
Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice. Huang L, Belousova T, Chen M, DiMattia G, Liu D, Sheikh-Hamad D. Kidney international. 2012 82:867-77. (WB; Human) [Full Text Article] [PubMed:22695329] Related Antibodies: LS-B3249.
6
Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation. Kakarla M, Puppala VK, Tyagi S, Anger A, Repp K, Wang J, Ying R, Widlansky ME. Cardiovascular Diabetology. 2019 November;18:148. [Full Text Article] [PubMed:31706320] [PMC:PMC6842161]
7
Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. Dajun Liu, Luping Huang, Yanlin Wang, Wei Wang, Xander H T Wehrens, Tatiana Belousova, Maen Abdelrahim, Gabriel DiMattia, David Sheikh-Hamad. PloS one. 2012 June;7:e36994. [Full Text Article] [PubMed:22693564] [PMC:PMC3365029] Related Antibodies: LS-B3249.
8
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA. Cell. 2014 May;157:882-96. [Full Text Article] [PubMed:24813611] Related Antibodies: LS-B3249.
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UCP2 Protein - Recombinant Uncoupling Protein 2, Mitochondrial By SDS-PAGE
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UCP2 Protein - Recombinant Uncoupling Protein 2, Mitochondrial By SDS-PAGE
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UCP2 Protein - 12.5% SDS-PAGE of human UCP2 stained with Coomassie Blue
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).