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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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UCP2

uncoupling protein 2 (mitochondrial, proton carrier)

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'.

Gene Name: uncoupling protein 2 (mitochondrial, proton carrier)
Family/Subfamily: Transporter , Mitochondrial carrier
Synonyms: UCP2, BMIQ4, UCP 2, Uncoupling protein 2, UCPH, SLC25A8
Target Sequences: NM_003355 NP_003346.2 P55851

Publications (6)

1
Uncoupling protein 2 expression in colon cancer and its clinical significance. Kuai Xiao Yi, Li Zhengyang, Steffi. World journal of gastroenterology : WJG. 2010 16:5773-8. (IHC-Fr; Human) [Full Text Article] [PubMed:21128330] [PMC:PMC2997996]
2
Uncoupling protein 2 regulates glucagon-like peptide-1 secretion in L-cells. Chen Y, Li ZY, Yang Y, Zhang HJ. World journal of gastroenterology : WJG. 2012 18:3451-7. (ICC, WB; Human) [Full Text Article] [PubMed:22807616] [PMC:PMC3396199]
3
Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I. Sharma S, Sun X, Kumar S, Rafikov R, Aramburo A, Kalkan G, Tian J, Rehmani I, Kallarackal S, Fineman JR, Black SM. Free radical biology & medicine. 2012 53:216-29. (WB; Human) [Full Text Article] [PubMed:22583703] [PMC:PMC3527085]
4
AKI after conditional and kidney-specific knockdown of stanniocalcin-1. Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D. Journal of the American Society of Nephrology : JASN. 2014 25:2303-15. (IHC, WB; Mouse) [Full Text Article] [PubMed:24700878] [PMC:PMC4178431] Related Antibodies: LS-B3249.
5
Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice. Huang L, Belousova T, Chen M, DiMattia G, Liu D, Sheikh-Hamad D. Kidney international. 2012 82:867-77. (WB; Human) [Full Text Article] [PubMed:22695329] Related Antibodies: LS-B3249.
6
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. Fang EF, Scheibye-Knudsen M, Brace LE, Kassahun H, SenGupta T, Nilsen H, Mitchell JR, Croteau DL, Bohr VA. Cell. 2014 May;157:882-96. [Full Text Article] [PubMed:24813611] Related Antibodies: LS-B3249.
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Viewing 1-25 of 53 items
UCP2 Antibody - Anti-UCP2 antibody IHC of human adipocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
Select
(3) Publication(s)
Goat Polyclonal to Human UCP2
Xenopus, Bat, Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
UCP2 Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human UCP2
Human
ELISA, IHC-P
Unconjugated
50µg   $425.00
Select
Rabbit Polyclonal (IgG) to Human UCP2
Human
ELISA, WB
Unconjugated
100µg   $755.00
Select
Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP2
Mouse
ELISA, WB
Unconjugated
100µg   $755.00
UCP2 Antibody
Select
Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   $205.00; 60µl   $235.00; 120µl   $295.00; 200µl   $395.00
Select
Mouse Monoclonal [clone 3F1B9] (IgG2a) to Human UCP2
Human
ELISA, Flo
Unconjugated
0.1mg   $365.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP2
Mouse
ELISA, WB
Unconjugated
100µg   $755.00
Select
Rabbit Polyclonal (IgG) to Mouse UCP2
Mouse
ELISA, WB
Unconjugated
100µl   $725.00
UCP2 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Mouse Monoclonal [clone 6C8B3] (IgG1) to Human UCP2
Human
ELISA, WB
Unconjugated
0.1mg   $365.00
UCP2 Antibody - Immunohistochemical analysis of UCP2 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human UCP2
Mouse, Dog, Sheep, Bovine, Rat, Human
IHC, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
UCP2 Antibody - IHC of UCP2 (H113) pAb in paraffin-embedded human lung carcinoma tissue.
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Rabbit Polyclonal to Human UCP2
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
IHC
Unconjugated
60µl   0.62mg/ml   $235.00; 120µl   0.62mg/ml   $295.00; 200µl   0.62mg/ml   $395.00
UCP2 Antibody - Western blot of recombinant UCP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse UCP2
Mouse, Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $265.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $545.00
UCP2 Antibody - Western blot of recombinant UCP2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Mouse UCP2
Mouse, Human
WB
Biotin Conjugated
100µl   0.5mg/ml   $275.00; 200µl   0.5mg/ml   $315.00; 1ml   0.5mg/ml   $590.00
UCP2 Antibody - Western Blot; Sample: Recombinant UCP2, Human.
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Mouse Monoclonal [clone C12] (IgG2b,k) to Human UCP2
Human
WB
Unconjugated
20µl   1mg/ml   $205.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $305.00; 1ml   1mg/ml   $560.00
UCP2 Antibody - Western Blot; Sample: Recombinant UCP2, Human.
Select
Mouse Monoclonal [clone C12] (IgG2b,k) to Human UCP2
Human
WB
Biotin Conjugated
100µl   0.5mg/ml   $275.00; 200µl   0.5mg/ml   $325.00; 1ml   0.5mg/ml   $605.00
UCP2 Antibody - Western Blot; Sample: Recombinant UCP2, Human.
Select
Mouse Monoclonal [clone C12] (IgG2b,k) to Human UCP2
Human
WB
FITC Conjugated
100µl   0.5mg/ml   $285.00; 200µl   0.5mg/ml   $335.00; 1ml   0.5mg/ml   $665.00
UCP2 Antibody - Western Blot; Sample: Recombinant UCP2, Human.
Select
Mouse Monoclonal [clone C12] (IgG2b,k) to Human UCP2
Human
WB
Cy3 Conjugated
100µl   0.1mg/ml   $365.00; 200µl   0.1mg/ml   $455.00; 1ml   0.1mg/ml   $1,110.00
Select
Rabbit Polyclonal (IgG) to Human UCP2
Human
WB
Unconjugated
100µl   0.15mg/ml   $245.00
UCP2 Antibody - Western blot testing of 1) rat spleen, 2) rat heart, 3) rat brain, 4) mouse spleen, 5) mouse heart, 6) mouse brain and 7) human HeLa lysate with UCP2 antibody at 0.5ug/ml. Predicted molecular weight ~34 kDa.
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Rabbit Polyclonal (IgG) to Human UCP2
Mouse, Rat, Human
WB
Unconjugated
100µg   $435.00
UCP2 Antibody - Western blot analysis of UCP2 using anti-UCP2 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: rat spleen tissue lysate,Lane 2: rat cardiac muscle tissue lysate,Lane 3: rat brain tissue lysate,Lane 4: mouse spleen tissue lysate,Lane 5: mouse cardiac muscle tissue lysate,Lane 6: mouse brain tissue lysate,Lane 7: human Hela whole cell lysate. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-UCP2 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for UCP2 at approximately 33KD. The expected band size for UCP2 is at 33KD.
Select
Rabbit Polyclonal to Human UCP2
Human
WB
Unconjugated
100µg   $325.00
UCP2 Antibody
Select
Rabbit Polyclonal to Human UCP2
Rat, Human
WB
Unconjugated
20µl   0.5mg/ml   $205.00; 100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $305.00; 1ml   0.5mg/ml   $530.00

Viewing 1-25 of 53 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).