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UCP1 / UCP-1

uncoupling protein 1 (mitochondrial, proton carrier)

Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.

Gene Name: uncoupling protein 1 (mitochondrial, proton carrier)
Family/Subfamily: Transporter , Mitochondrial carrier
Synonyms: UCP1, Thermogenin, SLC25A7, UCP-1, UCP 1
Target Sequences: NM_021833 NP_068605.1 P25874

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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
UCP1 / UCP-1 (8)
No (8)
GST, N-terminus (1)
His (3)
His-GST (1)
His-SUMO (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
Rat (2)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Yeast (1)
UCP1 / UCP-1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
UCP1 / UCP-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.8 kDa
20 µg/$150
UCP1 / UCP-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
32.8 kDa
100 µg/$494
UCP1 / UCP-1 Protein
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Yeast
His
34.9 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
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E. coli
His-SUMO
48.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
UCP1 / UCP-1 Protein - Recombinant Uncoupling Protein 1, Mitochondrial By SDS-PAGE
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E. coli
His
14.5 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
UCP1 / UCP-1 Protein - Recombinant Uncoupling Protein 1, Mitochondrial By SDS-PAGE
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E. coli
His-GST
45.0 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
UCP1 / UCP-1 Protein - Recombinant Uncoupling Protein 1, Mitochondrial By SDS-PAGE
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E. coli
His
14.6 kDa
10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).