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UCHL5 / UCH37

ubiquitin carboxyl-terminal hydrolase L5

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Gene Name: ubiquitin carboxyl-terminal hydrolase L5
Family/Subfamily: Protease , Cysteine C12
Synonyms: UCHL5, CGI-70, INO80 complex subunit R, INO80R, Ubiquitin thioesterase L5, UCH37, UCH-L5
Target Sequences: NM_015984 NP_057068.1 Q9Y5K5

Publications (1)

1
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor- receptor I expression and hypertrophy in mesangial cells. Krmer OH, Mller S, Buchwald M, Reichardt S, Heinzel T. Archives of biochemistry and biophysics. 2013 [PubMed:23500140] Related Antibodies: LS-C99521.

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Proteins (8)
Recombinant (8)
UCHL5 / UCH37 (8)
No (8)
GST (1)
GST, N-terminus (1)
His (4)
His-SUMO (1)
Myc-DDK (Flag) (1)
Bovine (1)
Human (6)
Mouse (1)
E. coli (5)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
Biologically active (1)
UCHL5 / UCH37 Protein - 12.5% SDS-PAGE of human UCHL5 stained with Coomassie Blue
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Wheat Germ Extract
GST
61.71 kDa
10 µg/$479; 25 µg/$670
UCHL5 / UCH37 Protein
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E. coli
His-SUMO
53.3 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
UCHL5 / UCH37 Protein - Purified recombinant protein UCHL5 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
37.4 kDa
20 µg/$1,107
UCHL5 / UCH37 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
UCHL5 / UCH37 Protein
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E. coli
His
Biologically active
100 µg/$361; 500 µg/$739; 20 µg/$261
UCHL5 / UCH37 Protein - Recombinant Ubiquitin Carboxyl Terminal Hydrolase L5 By SDS-PAGE
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E. coli
His
26.6 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
UCHL5 / UCH37 Protein - Recombinant Ubiquitin Carboxyl Terminal Hydrolase L5 By SDS-PAGE
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E. coli
His
37.5 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
UCHL5 / UCH37 Protein - Recombinant Ubiquitin Carboxyl Terminal Hydrolase L5 By SDS-PAGE
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E. coli
His
24.5 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).