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UCHL5 / UCH37

ubiquitin carboxyl-terminal hydrolase L5

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Gene Name: ubiquitin carboxyl-terminal hydrolase L5
Family/Subfamily: Protease , Cysteine C12
Synonyms: UCHL5, CGI-70, INO80 complex subunit R, INO80R, Ubiquitin thioesterase L5, UCH37, UCH-L5
Target Sequences: NM_015984 NP_057068.1 Q9Y5K5

Publications (1)

1
Ubiquitin C-terminal hydrolase-L5 is required for high glucose-induced transforming growth factor- receptor I expression and hypertrophy in mesangial cells. Krmer OH, Mller S, Buchwald M, Reichardt S, Heinzel T. Archives of biochemistry and biophysics. 2013 [PubMed:23500140] Related Antibodies: LS-C99521.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).