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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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UCHL3

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Gene Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Family/Subfamily: Protease , Cysteine C12
Synonyms: UCHL3, Ubiquitin thiolesterase, Ubiquitin thioesterase L3, UCH-L3
Target Sequences: NM_006002 NP_005993.1 P15374

Publications (4)

1
Transgenic rescue of ataxia mice reveals a male-specific sterility defect. Crimmins S, Sutovsky M, Chen PC, Huffman A, Wheeler C, Swing DA, Roth K, Wilson J, Sutovsky P, Wilson S. Developmental biology. 2009 325:33-42. (IHC-P; Mouse) [Full Text Article] [PubMed:18926813] [PMC:PMC2651617] Related Antibodies: LS-A8724.
2
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development. Mtango NR, Sutovsky M, Susor A, Zhong Z, Latham KE, Sutovsky P. Journal of cellular physiology. 2012 Apr;227:1592-603. [Full Text Article] [PubMed:21678411] [PMC:PMC4351554] Related Antibodies: LS-A8724.
3
Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation. Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P. Journal of cellular physiology. 2012 May;227:2022-9. [Full Text Article] [PubMed:21751213] [PMC:PMC4316209] Related Antibodies: LS-A8724.
4
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization. Yi YJ, Manandhar G, Sutovsky M, Li R, Jon[Character e1]kov[Character e1] V, Oko R, Park CS, Prather RS, Sutovsky P. Biology of reproduction. 2007 Nov;77:780-93. [Full Text Article] [PubMed:17671268] Related Antibodies: LS-A8724.
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Filtered by: None
Target
UCHL3 (74)
Reactivity
Human (58)
Mouse (41)
Rat (43)
Bovine (22)
Chicken (7)
Chimpanzee (6)
Dog (29)
Gibbon (3)
Guinea pig (8)
Hamster (7)
Horse (22)
Monkey (22)
Orangutan (3)
Pig (15)
Rabbit (15)
Zebrafish (7)
Application
IHC (41)
IHC-Fr (7)
IHC-P (35)
WB (44)
ELISA (17)
IF (7)
IP (7)
Host
rabbit (71)
mouse (3)
Isotype
IgG (15)
IgG2a,k (1)
IgG2b,k (1)
Clonality
monoclonal mc (3)
polyclonal pc (71)
Clone
4E9 (1)
Format
AP Conjugated (3)
APC (2)
APC Conjugated (5)
Azide-free (3)
Biotin Conjugated (8)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (5)
Unconjugated (33)
Epitope
aa2-230 (17)
Internal (14)
C-Terminus (11)
N-Terminus (4)
aa101-150 (4)
Leu220 (1)
aa1-220 (1)
aa1-50 (1)
aa174-224 (1)
Publications
No (73)
Yes (1)
Showing 1-25 of 74 results

IHC-plus™ UCHL3 Antibody (C-Terminus) LS-A8724
Publications (4)
Publications (4)
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, Biotin) LS-A108193
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, FITC) LS-A108194
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
FITC Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, Azide-free, HRP) LS-A108195
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, PE) LS-A108196
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
PE Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, APC) LS-A108192
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
APC Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus, AP) LS-A108191
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
AP Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-UCHL3 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (C-Terminus) LS-B12741
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ UCHL3 Antibody (Internal) LS-A8555
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, Biotin) LS-A108037
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, FITC) LS-A108038
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, APC) LS-A108036
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, AP) LS-A108035
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, Azide-free, HRP) LS-A108039
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal, PE) LS-A108040
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ UCHL3 Antibody (Internal) LS-A8557
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
Unconjugated
50µg 1mg/ml  $425.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ UCHL3 Antibody (Internal, FITC) LS-A108044
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ UCHL3 Antibody (Internal, AP) LS-A108041
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
AP Conjugated
100µl  $650.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ UCHL3 Antibody (Internal, APC) LS-A108042
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
APC Conjugated
100µl  $650.00
Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)

IHC-plus™ UCHL3 Antibody LS-B7856
Mouse Monoclonal (IgG2b,k) to Human UCHL3
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $425.00
Anti-UCHL3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot Image

IHC-plus™ UCHL3 Antibody (N-Terminus) LS-B4688
Rabbit Polyclonal (IgG) to Human UCHL3
Zebrafish, Pig, Horse, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-UCHL3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
UCHL3 antibody Western blot of MCF7 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

UCHL3 Antibody LS-C489729
Rabbit Polyclonal to Mouse UCHL3
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

UCHL3 Antibody LS-C489726
Rabbit Polyclonal to Rat UCHL3
Rat
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl  $275.00; 100µl  $355.00

UCHL3 Antibody LS-C772066
Rabbit Polyclonal (IgG) to Human UCHL3
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl 0.3mg/ml  $205.00; 60µl 0.3mg/ml  $235.00; 120µl 0.3mg/ml  $295.00; 200µl 0.3mg/ml  $395.00

UCHL3 Antibody LS-C661415
Rabbit Polyclonal (IgG) to Human UCHL3
Human
ELISA, IHC, WB
Unconjugated
100µg  $435.00
Showing 1-25 of 74 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).