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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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UCHL3

ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.

Gene Name: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Family/Subfamily: Protease , Cysteine C12
Synonyms: UCHL3, Ubiquitin thiolesterase, Ubiquitin thioesterase L3, UCH-L3
Target Sequences: NM_006002 NP_005993.1 P15374

Publications (4)

1
Transgenic rescue of ataxia mice reveals a male-specific sterility defect. Crimmins S, Sutovsky M, Chen PC, Huffman A, Wheeler C, Swing DA, Roth K, Wilson J, Sutovsky P, Wilson S. Developmental biology. 2009 325:33-42. (IHC-P; Mouse) [Full Text Article] [PubMed:18926813] [PMC:PMC2651617] Related Antibodies: LS-A8724.
2
Essential role of maternal UCHL1 and UCHL3 in fertilization and preimplantation embryo development. Mtango NR, Sutovsky M, Susor A, Zhong Z, Latham KE, Sutovsky P. Journal of cellular physiology. 2012 Apr;227:1592-603. [Full Text Article] [PubMed:21678411] [PMC:PMC4351554] Related Antibodies: LS-A8724.
3
Essential role of ubiquitin C-terminal hydrolases UCHL1 and UCHL3 in mammalian oocyte maturation. Mtango NR, Sutovsky M, Vandevoort CA, Latham KE, Sutovsky P. Journal of cellular physiology. 2012 May;227:2022-9. [Full Text Article] [PubMed:21751213] [PMC:PMC4316209] Related Antibodies: LS-A8724.
4
Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization. Yi YJ, Manandhar G, Sutovsky M, Li R, Jon[Character e1]kov[Character e1] V, Oko R, Park CS, Prather RS, Sutovsky P. Biology of reproduction. 2007 Nov;77:780-93. [Full Text Article] [PubMed:17671268] Related Antibodies: LS-A8724.
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Viewing 1-25 of 73 items
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
Biotin Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
FITC Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
APC Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
PE Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IF, IHC, IHC-Fr, IHC-P
AP Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Dog, Bovine, Horse, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
Unconjugated
50µg   1mg/ml   $425.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
UCHL3 Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Fast Shipping
Rabbit Polyclonal to Human UCHL3
Chicken, Mouse, Dog, Rat, Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
UCHL3 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human UCHL3
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Mouse Monoclonal (IgG2b,k) to Human UCHL3
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
UCHL3 Antibody - Anti-UCHL3 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human UCHL3
Zebrafish, Pig, Horse, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
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Rabbit Polyclonal to Mouse UCHL3
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00

Viewing 1-25 of 73 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).