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UCHL1 / PGP9.5

ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)

Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.

Gene Name:	ubiquitin carboxyl-terminal hydrolase L1 (ubiquitin thiolesterase)
Family/Subfamily:	Protease , Cysteine C12
Synonyms:	UCHL1, Ubiquitin C-terminal hydrolase, PARK5, PGP9.5, PGP95, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP 9.5, Uch-L1, Ubiquitin carboxyl-terminal esterase L1, HEL-117, NDGOA, HEL-S-53, SPG79
Target Sequences:	NM_004181 NP_004172.2 P09936

Publications (4)

Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system. Liu YA, Chen Y, Chiang AS, Peng SJ, Pasricha PJ, Tang SC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2011 23:e446-57. (IHC) [PubMed:21895876]

Control of BACE1 degradation and APP processing by ubiquitin carboxyl-terminal hydrolase L1. Zhang M, Deng Y, Luo Y, Zhang S, Zou H, Cai F, Wada K, Song W. Journal of neurochemistry. 2012 120:1129-38. [PubMed:22212137]

The fetal ovary exhibits temporal sensitivity to a 'real-life' mixture of environmental chemicals. Lea RG, Amezaga MR, Loup B, Mandon-Pépin B, Stefansdottir A, Filis P, Kyle C, Zhang Z, Allen C, Purdie L, Jouneau L, Cotinot C, Rhind SM, Sinclair KD, Fowler PA. Scientific reports. 2016 6:22279. (WB; Human) [Full Text Article] [PubMed:26931299] [PMC:PMC4773987] Related Antibodies: LS-B489.

Multifarious proteomic signatures and regional heterogeneity in glioblastomas. Park CK, Jung JH, Park SH, Jung HW, Cho BK. Journal of neuro-oncology. 2009 Aug;94:31-9. [Full Text Article] [PubMed:19219580] Related Antibodies: LS-B490.

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