E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions. Mediates ubiquitination of ACLY, leading to its subsequent degradation.
|Gene Name:||ubiquitin protein ligase E3 component n-recognin 4|
|Synonyms:||UBR4, p600, RBAF600, N-recognin-4, Zinc finger, UBR1 type 1, ZUBR1, RP5-1126H10.1, KIAA0462, KIAA1307|
|Target Sequences:||AF055010 AAC09360.1 Q5T4S7|
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