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Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 By similarity. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Gene Name: | upstream binding protein 1 (LBP-1a) |
Synonyms: | UBP1, LBP1, LBP-1a, LBP1A, LBP1B, Transcription factor LBP-1, Upstream-binding protein 1, LBP-1B |
Target Sequences: | NM_014517 NP_055332.3 Q9NZI7 |
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