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UBE2M / UBC12

ubiquitin-conjugating enzyme E2M

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Gene Name:	ubiquitin-conjugating enzyme E2M
Synonyms:	UBE2M, NEDD8 protein ligase, NEDD8 carrier protein, NEDD8-conjugating enzyme Ubc12, HUbc12, UBC-RS2, UBC12, Ubiquitin-protein ligase M, Yeast UBC12 homolog, Ubiquitin carrier protein M
Target Sequences:	NM_003969 NP_003960.1 P61081

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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